Pseudomonas aeruginosa LESB58, PALES_21321 (cifR)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_21321
|
| Name |
cifR
|
| Replicon | chromosome |
| Genomic location | 2307937 - 2308527 (+ strand) |
Cross-References
| RefSeq | |
| GI | 218890871 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
CifR
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -1.61 |
| Kyte-Doolittle Hydrophobicity Value | -0.189 |
| Molecular Weight (kDa) | 21.7 |
| Isoelectric Point (pI) | 5.89 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 6NSM | TRANSCRIPTION/DNA | 01/25/19 | TetR family transcriptional regulator CifR C99T-C107S-C181R Cysteines mutant complexed with 26bp double-strand operator DNA | Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT | 2.8 | X-RAY DIFFRACTION | 98.0 |
| 6NSR | TRANSCRIPTION/DNA | 01/25/19 | TetR family transcriptional regulator CifR C99T-C181R cysteine mutant complexed with 26bp double-strand operator DNA and apo-CifR C99T-C181R | Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT | 3 | X-RAY DIFFRACTION | 98.5 |
| 6NSN | TRANSCRIPTION/DNA | 01/25/19 | TetR family transcriptional regulator CifR C99T-C181R Cysteines mutant complexed with 26bp double-strand operator DNA | Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT | 2.6 | X-RAY DIFFRACTION | 98.5 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 231 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000241 (6008 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_21321
Search term: cifR
Search term: CifR
|
Human Homologs
References
|
Cif is negatively regulated by the TetR family repressor CifR.
MacEachran DP, Stanton BA, O'Toole GA
Infect Immun 2008 Jul;76(7):3197-206
PubMed ID: 18458065
|