Pseudomonas aeruginosa PAO1, PA2492 (mexT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA2492
Name
mexT
Replicon chromosome
Genomic location 2807469 - 2808512 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_251182.1
GI 15597688
Affymetrix PA2492_mexT_at
Entrez 880417
GenBank AAG05880.1
NCBI Locus Tag PA2492
protein_id(GenBank) gb|AAG05880.1|AE004676_12|gnl|PseudoCAP|PA2492
TIGR NTL03PA02492
UniProtKB Acc Q9I0Z0
UniProtKB ID Q9I0Z0_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator MexT
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 6.19
Kyte-Doolittle Hydrophobicity Value -0.405
Molecular Weight (kDa) 38.2
Isoelectric Point (pI) 10.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexT MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN, OprD, and MexS. ARO:3000814 protein overexpression model Strict 676.8 100.0 3.0.2

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 185 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001179 (1988 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2492
Search term: mexT

References

Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa.
Köhler T, Michéa-Hamzehpour M, Henze U, Gotoh N, Curty LK, Pechère JC
Mol. Microbiol. 1997 Jan;23(2):345-54
PubMed ID: 9044268
MexT regulates the type III secretion system through MexS and PtrC in Pseudomonas aeruginosa.
Jin Y, Yang H, Qiao M, Jin S
J. Bacteriol. 2011 Jan;193(2):399-410
PubMed ID: 21075931