Pseudomonas aeruginosa PAO1, PA0030 (cosX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0030
Name
cosX
Replicon chromosome
Genomic location 32060 - 32983 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentCholine-O-sulfate (COS)-specific binding protein, interacting with CbcVW to import COS, which will be hydrolyzed into choline
CommentCholine-O-sulfate (COS)-specific binding protein, interacting with CbcVW to import COS, which will be hydrolyzed into choline

Cross-References

RefSeq NP_248720.1
GI 15595228
Affymetrix PA0030_at
Entrez 880659
GenBank AAG03420.1
INSDC AAG03420.1
NCBI Locus Tag PA0030
protein_id(GenBank) gb|AAG03420.1|AE004442_7|gnl|PseudoCAP|PA0030
TIGR NTL03PA00031
UniParc UPI00000C4EF4
UniProtKB Acc Q9I7A0
UniProtKB ID Q9I7A0_PSEAE
UniRef100 UniRef100_Q9I7A0
UniRef50 UniRef50_D5AQ73
UniRef90 UniRef90_Q9I7A0

Product

Feature Type CDS
Coding Frame 1
Product Name
CosX
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 1.11
Kyte-Doolittle Hydrophobicity Value -0.255
Molecular Weight (kDa) 33.9
Isoelectric Point (pI) 7.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 131 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000030 (491 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0030
Search term: cosX
Search term: CosX

Human Homologs

References

The widespread plant-colonizing bacterial species Pseudomonas syringae detects and exploits an extracellular pool of choline in hosts.
Chen C, Li S, McKeever DR, Beattie GA
Plant J 2013 Sep;75(6):891-902
PubMed ID: 23763788