Pseudomonas aeruginosa PAO1, PA0035 (trpA)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0000162	tryptophan biosynthetic process	NAS Non-traceable Author Statement	ECO:0000303 non-traceable author statement used in manual assertion	3127651	Reviewed by curator
Biological Process	GO:0000162	tryptophan biosynthetic process	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	3127651	Reviewed by curator
Biological Process	GO:0006520	cellular amino acid metabolic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	3127651	Reviewed by curator
Molecular Function	GO:0004834	tryptophan synthase activity	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	3127651	Reviewed by curator
Biological Process	GO:0000162	tryptophan biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	3127651	Reviewed by curator
Molecular Function	GO:0004834	tryptophan synthase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00290	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006568	tryptophan metabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00290	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01230	Biosynthesis of amino acids	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	COMPLETE-ARO-PWY	superpathway of aromatic amino acid biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	ALL-CHORISMATE-PWY	superpathway of chorismate metabolism	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00400	Phenylalanine, tyrosine and tryptophan biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Phenylalanine, tyrosine and tryptophan biosynthesis		ECO:0000037 not_recorded
KEGG	pae01130	Biosynthesis of antibiotics	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00260	Glycine, serine and threonine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	TRPSYN-PWY	L-tryptophan biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
CDD	cd04724	Tryptophan_synthase_alpha	IPR002028	Tryptophan synthase, alpha chain	18	260	2.07603E-121
Hamap	MF_00131	Tryptophan synthase alpha chain [trpA].	IPR002028	Tryptophan synthase, alpha chain	14	263	38.09428
Pfam	PF00290	Tryptophan synthase alpha chain	IPR002028	Tryptophan synthase, alpha chain	8	263	3.2E-106
NCBIfam	TIGR00262	JCVI: tryptophan synthase subunit alpha	IPR002028	Tryptophan synthase, alpha chain	8	259	3.2E-81
Gene3D	G3DSA:3.20.20.70	Aldolase class I	IPR013785	Aldolase-type TIM barrel	1	268	1.9E-104
PANTHER	PTHR43406	TRYPTOPHAN SYNTHASE, ALPHA CHAIN	IPR002028	Tryptophan synthase, alpha chain	3	262	8.2E-85
FunFam	G3DSA:3.20.20.70:FF:000037	Tryptophan synthase alpha chain	-	-	1	266	4.4E-101
SUPERFAMILY	SSF51366	Ribulose-phoshate binding barrel	IPR011060	Ribulose-phosphate binding barrel	1	248	1.51E-92

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.