Pseudomonas aeruginosa PAO1, PA0336 (rppH)

Cytoplasmic Membrane
Outer Membrane
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009117 nucleotide metabolic process
Inferred from Sequence or Structural Similarity
sequence similarity evidence
Molecular Function GO:0034353 RNA pyrophosphohydrolase activity
Inferred from Mutant Phenotype
mutant phenotype evidence used in manual assertion
28833678 Reviewed by curator
Molecular Function GO:0016787 hydrolase activity
Inferred from Sequence Model
Term mapped from: InterPro:SSF55811
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class


Database Xref Pathway Version Evidence PMID
KEGG pae03018 RNA degradation 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd03671 Ap4A_hydrolase_plant_like IPR022927 RNA pyrophosphohydrolase RppH 6 151 8.28002E-71
PRINTS PR00502 NUDIX hydrolase family signature IPR020476 NUDIX hydrolase 33 47 1.4E-6
PRINTS PR00502 NUDIX hydrolase family signature IPR020476 NUDIX hydrolase 47 62 1.4E-6
SUPERFAMILY SSF55811 IPR015797 NUDIX hydrolase-like domain superfamily 3 154 1.31E-29
ProSiteProfiles PS51462 Nudix hydrolase domain profile. IPR000086 NUDIX hydrolase domain 6 149 19.65
Pfam PF00293 NUDIX domain IPR000086 NUDIX hydrolase domain 7 146 8.9E-26
Gene3D G3DSA: 1 157 2.2E-43
Hamap MF_00298 RNA pyrophosphohydrolase [rppH]. IPR022927 RNA pyrophosphohydrolase RppH 1 156 37.511
ProSitePatterns PS00893 Nudix box signature. IPR020084 NUDIX hydrolase, conserved site 38 59 -

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.