Pseudomonas aeruginosa PAO1, PA3165 (hisC2)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0000105	histidine biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	22232166	Reviewed by curator
Biological Process	GO:0006520	cellular amino acid metabolic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0030170	pyridoxal phosphate binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00155	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009058	biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00155	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004400	histidinol-phosphate transaminase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_01023	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0000105	histidine biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_01023	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00360	Phenylalanine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01230	Biosynthesis of amino acids	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00350	Tyrosine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Phenylalanine, tyrosine and tryptophan biosynthesis		ECO:0000037 not_recorded
PseudoCyc	BSUBPHENYLSYN-PWY	phenylalanine biosynthesis, Bacillus subtilis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00400	Phenylalanine, tyrosine and tryptophan biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00401	Novobiocin biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01130	Biosynthesis of antibiotics	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Histidine metabolism		ECO:0000037 not_recorded
KEGG	pae00340	Histidine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Phenylalanine metabolism		ECO:0000037 not_recorded

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Pfam	PF00155	Aminotransferase class I and II	IPR004839	Aminotransferase, class I/classII	38	362	3.4E-50
NCBIfam	TIGR01141	JCVI: histidinol-phosphate transaminase	IPR005861	Histidinol-phosphate aminotransferase family	10	364	2.2E-116
Hamap	MF_01023	Histidinol-phosphate aminotransferase [hisC].	IPR005861	Histidinol-phosphate aminotransferase family	7	366	62.80201
Gene3D	G3DSA:3.90.1150.10	Aspartate Aminotransferase, domain 1	IPR015422	Pyridoxal phosphate-dependent transferase, small domain	29	362	1.1E-115
Gene3D	G3DSA:3.40.640.10	-	IPR015421	Pyridoxal phosphate-dependent transferase, major domain	50	274	1.1E-115
SUPERFAMILY	SSF53383	PLP-dependent transferases	IPR015424	Pyridoxal phosphate-dependent transferase	17	366	4.31E-81
PANTHER	PTHR43643	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE 2	-	-	11	366	4.9E-104
CDD	cd00609	AAT_like	-	-	39	364	2.85655E-61

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.