Pseudomonas aeruginosa PAO1, PA0004 (gyrB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0042493 response to drug
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
9144789 Reviewed by curator
Molecular Function GO:0005524 ATP binding
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
9756859 Reviewed by curator
Molecular Function GO:0003677 DNA binding
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
6294616 Reviewed by curator
Biological Process GO:0006265 DNA topological change
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
6327603 Reviewed by curator
Molecular Function GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
368801 Reviewed by curator
Biological Process GO:0006351 transcription, DNA-templated
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
15535863 Reviewed by curator
Cellular Component GO:0005694 chromosome
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01898
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00204
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00204
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006265 DNA topological change
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00204
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00204
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

DNA replication, recombination, modification and repair Other PAO1 genes in this class

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.50.670 IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal 706 805 2.7E-26
PRINTS PR00418 DNA topoisomerase II family signature 37 52 9.7E-72
Gene3D G3DSA:3.40.50.670 IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal 398 586 2.4E-74
ProSiteProfiles PS50880 Toprim domain profile. IPR006171 TOPRIM domain 420 535 21.599
CDD cd16928 HATPase_GyrB-like 38 217 3.13342E-105
PRINTS PR00418 DNA topoisomerase II family signature 422 436 9.7E-72
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 759 771 1.8E-83
Hamap MF_01898 DNA gyrase subunit B [gyrB]. IPR011557 DNA gyrase, subunit B 4 806 101.231
Pfam PF00204 DNA gyrase B IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 222 392 6.5E-57
PRINTS PR00418 DNA topoisomerase II family signature 738 754 9.7E-72
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 362 376 1.8E-83
Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPR003594 Histidine kinase/HSP90-like ATPase 34 175 2.9E-22
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 376 396 1.8E-83
Gene3D G3DSA:3.30.565.10 IPR036890 Histidine kinase/HSP90-like ATPase superfamily 3 220 2.6E-92
SUPERFAMILY SSF55874 IPR036890 Histidine kinase/HSP90-like ATPase superfamily 7 219 5.24E-75
SUPERFAMILY SSF56719 IPR013760 DNA topoisomerase, type IIA-like domain superfamily 396 796 2.59E-88
ProSitePatterns PS00177 DNA topoisomerase II signature. IPR018522 DNA topoisomerase, type IIA, conserved site 424 432 -
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 7 17 1.8E-83
PRINTS PR00418 DNA topoisomerase II family signature 527 539 9.7E-72
Pfam PF00986 DNA gyrase B subunit, carboxyl terminus IPR002288 DNA gyrase B subunit, C-terminal 734 795 1.1E-30
PRINTS PR00418 DNA topoisomerase II family signature 115 129 9.7E-72
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 775 791 1.8E-83
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 314 330 1.8E-83
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 182 197 1.8E-83
CDD cd00822 TopoII_Trans_DNA_gyrase 221 379 3.18741E-75
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 221 243 1.8E-83
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 197 210 1.8E-83
Gene3D G3DSA:3.30.230.10 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup 221 397 1.6E-68
PRINTS PR00418 DNA topoisomerase II family signature 72 85 9.7E-72
Gene3D G3DSA:3.10.20.690 594 685 1.6E-19
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 472 481 1.8E-83
CDD cd03366 TOPRIM_TopoIIA_GyrB IPR034160 DNA gyrase subunit B, TOPRIM domain 420 534 1.11291E-79
SMART SM00387 IPR003594 Histidine kinase/HSP90-like ATPase 33 177 2.5E-30
PRINTS PR00418 DNA topoisomerase II family signature 507 524 9.7E-72
SMART SM00433 IPR001241 DNA topoisomerase, type IIA 37 799 0.0
TIGRFAM TIGR01059 gyrB: DNA gyrase, B subunit IPR011557 DNA gyrase, subunit B 7 806 0.0
PRINTS PR00418 DNA topoisomerase II family signature 489 505 9.7E-72
SUPERFAMILY SSF54211 IPR020568 Ribosomal protein S5 domain 2-type fold 222 394 2.85E-57
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 244 262 1.8E-83
PRINTS PR00418 DNA topoisomerase II family signature 270 283 9.7E-72
Pfam PF01751 Toprim domain IPR006171 TOPRIM domain 421 533 1.7E-17
Pfam PF18053 DNA gyrase B subunit insert domain IPR041423 DNA gyrase subunit B insert domain 566 732 3.1E-52

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.