Pseudomonas aeruginosa UCBPP-PA14, PA14_00290 (aroE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR21089
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00507
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0019632 shikimate metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00507
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00400 Phenylalanine, tyrosine and tryptophan biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.50.10860 Leucine Dehydrogenase, chain A, domain 1 - - 6 255 7.0E-87
FunFam G3DSA:3.40.50.10860:FF:000006 Shikimate dehydrogenase (NADP(+)) - - 5 120 2.1E-42
NCBIfam TIGR00507 JCVI: shikimate dehydrogenase IPR011342 Shikimate dehydrogenase 4 271 2.0E-75
PANTHER PTHR21089 SHIKIMATE DEHYDROGENASE IPR022893 Shikimate dehydrogenase family 2 259 1.5E-59
CDD cd01065 NAD_bind_Shikimate_DH - - 100 255 1.48242E-40
SUPERFAMILY SSF53223 Aminoacid dehydrogenase-like, N-terminal domain IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily 1 100 1.09E-30
Pfam PF18317 Shikimate 5'-dehydrogenase C-terminal domain IPR041121 SDH, C-terminal 238 267 3.4E-11
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 101 270 1.21E-36
Pfam PF08501 Shikimate dehydrogenase substrate binding domain IPR013708 Shikimate dehydrogenase substrate binding, N-terminal 6 87 5.5E-24
Hamap MF_00222 Shikimate dehydrogenase (NADP(+)) [aroE]. IPR022893 Shikimate dehydrogenase family 1 270 31.371649
Gene3D G3DSA:3.40.50.720 - - - 101 245 7.0E-87
FunFam G3DSA:3.40.50.720:FF:000104 Shikimate dehydrogenase (NADP(+)) - - 101 245 2.6E-59
Pfam PF01488 Shikimate / quinate 5-dehydrogenase IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase 116 165 4.3E-7

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.