Pseudomonas aeruginosa UCBPP-PA14, PA14_49300

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_49300
Name
Replicon	chromosome
Genomic location	4379275 - 4381332 (- strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	3 transposon mutants in orthologs

Cross-References

RefSeq	YP_792097.1
GI	116049101
Entrez	4380117
INSDC	ABJ10337.1
NCBI Locus Tag	PA14_49300
UniParc	UPI0000E44B55
UniProtKB Acc	Q02IY9
UniProtKB ID	Q02IY9_PSEAB
UniRef100	UniRef100_S0IWY1
UniRef50	UniRef50_Q8RNT4
UniRef90	UniRef90_Q8RNT4

Product

Feature Type	CDS
Coding Frame	1
Product Name	lipoxygenase
Synonyms
Evidence for Translation
Charge (pH 7)	-2.42
Kyte-Doolittle Hydrophobicity Value	0.033
Molecular Weight (kDa)	74.6
Isoelectric Point (pI)	6.60

Subcellular localization

Individual Mappings	Localization Confidence PMID Periplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5IR4	OXIDOREDUCTASE	03/12/16	Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group C2221 at 1.48 A resolution	Pseudomonas aeruginosa	1.48	X-RAY DIFFRACTION	99.1
5LC8	OXIDOREDUCTASE	06/20/16	Crystal Structure of specific mutant from Pseudomonas aeruginosa Lipoxygenase at 1.8A resolution	Pseudomonas aeruginosa	1.8	X-RAY DIFFRACTION	99.4
4RPE	OXIDOREDUCTASE	10/30/14	Crystal Structure of Variant G186E from Pseudomonas Aeruginosa Lipoxygenase 2 at 1.60A (C2)	Pseudomonas aeruginosa	1.6	X-RAY DIFFRACTION	99.0
5IR5	OXIDOREDUCTASE	03/12/16	Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group P21212 at 1.9 A resolution	Pseudomonas aeruginosa	1.9	X-RAY DIFFRACTION	99.1
4G32	OXIDOREDUCTASE	07/13/12	Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 1.75A (P21212)	Pseudomonas aeruginosa	1.75	X-RAY DIFFRACTION	99.1
4G33	OXIDOREDUCTASE	07/13/12	Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 2.0 A (C2221)	Pseudomonas aeruginosa	2.03	X-RAY DIFFRACTION	99.1

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 20 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001127 (298 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_49300 Search term: lipoxygenase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000369494 arachidonate lipoxygenase 3 [Source:HGNC Symbol;Acc:HGNC:13743] E-value: 2.6e-51 Percent Identity: 31.1
Ensembl 110, assembly GRCh38.p14	ENSP00000400581 arachidonate lipoxygenase 3 [Source:HGNC Symbol;Acc:HGNC:13743] E-value: 2.6e-51 Percent Identity: 31.1
Ensembl 110, assembly GRCh38.p14	ENSP00000314879 arachidonate lipoxygenase 3 [Source:HGNC Symbol;Acc:HGNC:13743] E-value: 2.6e-51 Percent Identity: 31.1

References