Pseudomonas aeruginosa PAO1, PA0058 (dsbM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0058
Name
dsbM
Replicon chromosome
Genomic location 72680 - 73384 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_248748.1
GI 15595256
Affymetrix PA0058_at
DNASU PaCD00006025
Entrez 880931
GenBank AAG03448.1
INSDC AAG03448.1
NCBI Locus Tag PA0058
protein_id(GenBank) gb|AAG03448.1|AE004445_9|gnl|PseudoCAP|PA0058
TIGR NTL03PA00059
UniParc UPI00000C4F0B
UniProtKB Acc Q9I774
UniProtKB ID Q9I774_PSEAE
UniRef100 UniRef100_Q9I774
UniRef50 UniRef50_V5UEA6
UniRef90 UniRef90_Z2DKX5

Product

Feature Type CDS
Coding Frame 1
Product Name
DsbM
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -5.74
Kyte-Doolittle Hydrophobicity Value 0.003
Molecular Weight (kDa) 24.9
Isoelectric Point (pI) 5.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold Protein Structure Database

Available for P. aeruginosa PAO1.

View predicted 3D structure in AlphaFold DB

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5HFG OXIDOREDUCTASE 01/07/16 Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 1.823 X-RAY DIFFRACTION 100.0
5HFI OXIDOREDUCTASE 01/07/16 Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa with GSH Pseudomonas aeruginosa PAO1 1.801 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 83 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000057 (372 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0058
Search term: dsbM
Search term: DsbM

Human Homologs

References

DsbM, a novel disulfide oxidoreductase affects aminoglycoside resistance in Pseudomonas aeruginosa by OxyR-regulated response.
Wang X, Li M, Liu L, Mou R, Zhang X, Bai Y, Xu H, Qiao M
J. Microbiol. 2012 Dec;50(6):932-8
PubMed ID: 23274979