Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0259
|
Name |
tla3
Synonym: tli3 |
Replicon | chromosome |
Genomic location | 289562 - 291004 (- strand) |
Transposon Mutants | 5 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
Comment | Tla3 is localized in the cytoplasm of P. aeruginosa and is required for Tle3 secretion and antibacterial activity in P. aeruginosa. Direct interaction with Tle3 and VgrG2b |
Comment | In a previous release, we updated the start site to 291154 based on a recombinant tla3 gene with this start site being used in E. coli. There is no evidence for 291154 being the translation initiation site in P. aeruginosa so it have been reverted back to 291004. |
RefSeq | NP_248950.1 |
GI | 15595456 |
Affymetrix | PA0259_at |
Entrez | 881892 |
GenBank | AAG03648.1 |
INSDC | AAG03648.1 |
NCBI Locus Tag | PA0259 |
protein_id(GenBank) | gb|AAG03648.1|AE004464_1|gnl|PseudoCAP|PA0259 |
TIGR | NTL03PA00260 |
UniParc | UPI00000C4FC8 |
UniProtKB Acc | Q9I6N0 |
UniProtKB ID | Q9I6N0_PSEAE |
UniRef100 | UniRef100_Q9I6N0 |
UniRef50 | UniRef50_Q9I6N0 |
UniRef90 | UniRef90_Q9I6N0 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Type 6 lipase adaptor, Tla3
|
Synonyms |
Tli3 |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -10.32 |
Kyte-Doolittle Hydrophobicity Value | -0.317 |
Molecular Weight (kDa) | 52.4 |
Isoelectric Point (pI) | 5.02 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 7 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000257 (262 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA0259
Search term: tla3
Search term: Type 6 lipase adaptor, Tla3
|
Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors.
Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD
Nature 2013 Apr 25;496(7446):508-12
PubMed ID: 23552891
|
A Type VI Secretion System Trans-Kingdom Effector Is Required for the Delivery of a Novel Antibacterial Toxin in Pseudomonas aeruginosa.
Berni B, Soscia C, Djermoun S, Ize B, Bleves S
Front Microbiol 2019;10:1218
PubMed ID: 31231326
|