Pseudomonas aeruginosa PAO1, PA0667 (mepM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0667
Name
mepM
Synonym: yebA
Replicon chromosome
Genomic location 718729 - 720072 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentPeptidoglycan cross-link hydrolase (based on homology to E.coli MepM)

Cross-References

RefSeq NP_249358.1
GI 15595864
Affymetrix PA0667_at
Entrez 878797
GenBank AAG04056.1
NCBI Locus Tag PA0667
protein_id(GenBank) gb|AAG04056.1|AE004501_8|gnl|PseudoCAP|PA0667
TIGR NTL03PA00668
UniProtKB Acc Q9I5Q4
UniProtKB ID Q9I5Q4_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
MepM
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 14.89
Kyte-Doolittle Hydrophobicity Value -0.543
Molecular Weight (kDa) 49.1
Isoelectric Point (pI) 9.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 526 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000646 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0667
Search term: mepM
Search term: MepM

Human Homologs

References

A Proteolytic Complex Targets Multiple Cell Wall Hydrolases in Pseudomonas aeruginosa.
Srivastava D, Seo J, Rimal B, Kim SJ, Zhen S, Darwin AJ
mBio 2018 Jul 17;9(4)
PubMed ID: 30018106