Pseudomonas aeruginosa PAO1, PA0792 (prpD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0792
Name
prpD
Replicon chromosome
Genomic location 867324 - 868808 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249483.1
GI 15595989
Affymetrix PA0792_prpD_at
Entrez 881990
GenBank AAG04181.1
INSDC AAG04181.1
NCBI Locus Tag PA0792
protein_id(GenBank) gb|AAG04181.1|AE004514_4|gnl|PseudoCAP|PA0792
TIGR NTL03PA00793
UniParc UPI00000C5155
UniProtKB Acc Q9I5E6
UniProtKB ID Q9I5E6_PSEAE
UniRef100 UniRef100_Q9I5E6
UniRef50 UniRef50_P77243
UniRef90 UniRef90_A6VAI3

Product

Feature Type CDS
Coding Frame 1
Product Name
propionate catabolic protein PrpD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.90
Kyte-Doolittle Hydrophobicity Value -0.140
Molecular Weight (kDa) 54.9
Isoelectric Point (pI) 6.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6S62 ISOMERASE 07/02/19 Crystal structure of 2-methylcitrate dehydratase (PrpD) from Pseudomonas aeruginosa in apo form. Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.36 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 150 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000765 (441 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0792
Search term: prpD

Human Homologs

References

Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon.
Horswill AR, Escalante-Semerena JC
J Bacteriol 1997 Feb;179(3):928-40
PubMed ID: 9006051