Pseudomonas aeruginosa UCBPP-PA14, PA14_52570 (rsmA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_52570
Name
rsmA
Replicon chromosome
Genomic location 4660393 - 4660578 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14

Cross-References

RefSeq YP_792371.1
GI 116048829
Entrez 4383136
INSDC ABJ10065.1
NCBI Locus Tag PA14_52570
UniParc UPI00001285B6
UniProtKB Acc Q02I65
UniProtKB ID CSRA_PSEAB
UniRef100 UniRef100_B7UY29
UniRef50 UniRef50_Q5E7G3
UniRef90 UniRef90_A4VJB5

Product

Feature Type CDS
Coding Frame 1
Product Name
carbon storage regulator
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 0.46
Kyte-Doolittle Hydrophobicity Value -0.446
Molecular Weight (kDa) 6.9
Isoelectric Point (pI) 7.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
rsmA rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA. [PMID:16622241, PMID:11673439] ARO:3005069 protein homolog model Perfect 117.1 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7YR6 RNA BINDING PROTEIN/RNA 08/09/22 Cryo-EM structure of Pseudomonas aeruginosa RsmZ RNA in complex with two RsmA protein dimers Pseudomonas aeruginosa 4.8 ELECTRON MICROSCOPY 100.0
1VPZ RNA BINDING PROTEIN 11/24/04 Crystal structure of a putative carbon storage regulator protein (csra, pa0905) from pseudomonas aeruginosa at 2.05 A resolution Pseudomonas aeruginosa 2.05 X-RAY DIFFRACTION 100.0
7YR7 RNA BINDING PROTEIN/RNA 08/09/22 Cryo-EM structure of Pseudomonas aeruginosa RsmZ RNA in complex with three RsmA protein dimers Pseudomonas aeruginosa 3.8 ELECTRON MICROSCOPY 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 227 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000872 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_52570
Search term: rsmA

Human Homologs

References

RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999