Pseudomonas aeruginosa UCBPP-PA14, PA14_53950 (prpC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_53950
Name
prpC
Replicon chromosome
Genomic location 4783274 - 4784401 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_792487.1
GI 116048713
EC Number 2.3.3.5
Entrez 4381662
INSDC ABJ09949.1
NCBI Locus Tag PA14_53950
UniParc UPI00000C5158
UniProtKB Acc Q02HU9
UniProtKB ID Q02HU9_PSEAB
UniRef100 UniRef100_W0YL54
UniRef50 UniRef50_Q56063
UniRef90 UniRef90_A6VAI0

Product

Feature Type CDS
Coding Frame 1
Product Name
methylcitrate synthase
Synonyms
Evidence for Translation
Charge (pH 7) -3.47
Kyte-Doolittle Hydrophobicity Value -0.234
Molecular Weight (kDa) 41.7
Isoelectric Point (pI) 6.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6S6F TRANSFERASE 07/03/19 Crystal structure of 2-methylcitrate synthase (PrpC) from Pseudomonas aeruginosa in apo form. Pseudomonas aeruginosa PAO1 1.53 X-RAY DIFFRACTION 100.0
6S87 TRANSFERASE 07/08/19 Crystal structure of 2-methylcitrate synthase (PrpC) from Pseudomonas aeruginosa in complex with oxaloacetate. Pseudomonas aeruginosa PAO1 1.65 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Caenorhabditis elegans
Notes
Infection model C. elegans slow killing assay.
Reference 22911607

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 550 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000768 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_53950
Search term: prpC

Human Homologs

References

No references are associated with this feature.