Pseudomonas aeruginosa PAO1, PA4023 (eat)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4023
Name
eat
Synonym: eutP
Replicon chromosome
Genomic location 4504001 - 4505449 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentPart of the PA4022-eat-eutBC operon responsible for ethanolamine catabolism.

Cross-References

RefSeq NP_252712.1
GI 15599218
Affymetrix PA4023_at
Entrez 879018
GenBank AAG07410.1
INSDC AAG07410.1
NCBI Locus Tag PA4023
protein_id(GenBank) gb|AAG07410.1|AE004819_3|gnl|PseudoCAP|PA4023
TIGR NTL03PA04023
UniParc UPI00000C5BC8
UniProtKB Acc Q9HX04
UniProtKB ID Q9HX04_PSEAE
UniRef100 UniRef100_X6ZB41
UniRef50 UniRef50_Q0RYW7
UniRef90 UniRef90_A6V084

Product

Feature Type CDS
Coding Frame 1
Product Name
ethanolamine transporter, Eat
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 0.52
Kyte-Doolittle Hydrophobicity Value 0.814
Molecular Weight (kDa) 50.8
Isoelectric Point (pI) 7.16

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 405 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001660 (522 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4023
Search term: eat

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Sequence of Rhodococcus gene cluster encoding the subunits of ethanolamine ammonia-lyase and an APC-like permease.
De Mot R, Nagy I, Schoofs G, Vanderleyden J
Can J Microbiol 1994 May;40(5):403-7
PubMed ID: 8069783
Ethanolamine Catabolism in Pseudomonas aeruginosa PAO1 Is Regulated by the Enhancer-Binding Protein EatR (PA4021) and the Alternative Sigma Factor RpoN.
Lundgren BR, Sarwar Z, Pinto A, Ganley JG, Nomura CT
J Bacteriol 2016 Sep 1;198(17):2318-29
PubMed ID: 27325678