Pseudomonas aeruginosa PAO1, PA4052 (nusB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4052
Name
nusB
Synonym: ssyB
Replicon chromosome
Genomic location 4533640 - 4534119 (- strand)

Cross-References

RefSeq NP_252741.1
GI 15599247
Affymetrix PA4052_nusB_at
DNASU PaCD00007771
Entrez 878643
GenBank AAG07439.1
INSDC AAG07439.1
NCBI Locus Tag PA4052
protein_id(GenBank) gb|AAG07439.1|AE004821_12|gnl|PseudoCAP|PA4052
TIGR NTL03PA04052
UniParc UPI0000130A60
UniProtKB Acc Q9HWX6
UniProtKB ID NUSB_PSEAE
UniRef100 UniRef100_Q9HWX6
UniRef50 UniRef50_Q9HWX6
UniRef90 UniRef90_Q9HWX6

Product

Feature Type CDS
Coding Frame 1
Product Name
NusB protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.92
Kyte-Doolittle Hydrophobicity Value -0.489
Molecular Weight (kDa) 17.7
Isoelectric Point (pI) 8.47

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 489 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001632 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4052
Search term: nusB
Search term: NusB protein

Human Homologs

References

Antiterminator-dependent modulation of transcription elongation rates by NusB and NusG.
Zellars M, Squires CL
Mol Microbiol 1999 Jun;32(6):1296-304
PubMed ID: 10383769
Insertional disruption of the nusB (ssyB) gene leads to cold-sensitive growth of Escherichia coli and suppression of the secY24 mutation.
Taura T, Ueguchi C, Shiba K, Ito K
Mol Gen Genet 1992 Sep;234(3):429-32
PubMed ID: 1406588