Pseudomonas aeruginosa PAO1, PA4078

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4078
Name
Replicon chromosome
Genomic location 4555254 - 4558229 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252767.1
GI 15599273
Affymetrix PA4078_at
Entrez 878689
GenBank AAG07465.1
INSDC AAG07465.1
NCBI Locus Tag PA4078
protein_id(GenBank) gb|AAG07465.1|AE004823_11|gnl|PseudoCAP|PA4078
TIGR NTL03PA04078
UniParc UPI00000C5BF8
UniProtKB Acc Q9HWV0
UniProtKB ID Q9HWV0_PSEAE
UniRef100 UniRef100_Q9HWV0
UniRef50 UniRef50_B9BRK2
UniRef90 UniRef90_A0A077JIW0

Product

Feature Type CDS
Coding Frame 1
Product Name
probable nonribosomal peptide synthetase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.96
Kyte-Doolittle Hydrophobicity Value -0.257
Molecular Weight (kDa) 110.4
Isoelectric Point (pI) 6.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 572 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001608 (362 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4078

Human Homologs

Ensembl 110, assembly GRCh38.p14
acyl-CoA synthetase short chain family member 3 [Source:HGNC Symbol;Acc:HGNC:24723]
E-value: 1.3e-14
Percent Identity: 21.6
Ensembl 110, assembly GRCh38.p14
acyl-CoA synthetase short chain family member 3 [Source:HGNC Symbol;Acc:HGNC:24723]
E-value: 1.3e-14
Percent Identity: 21.6

References

A new Myxococcus xanthus gene cluster for the biosynthesis of the antibiotic saframycin Mx1 encoding a peptide synthetase.
Pospiech A, Cluzel B, Bietenhader J, Schupp T
Microbiology (Reading) 1995 Aug;141 ( Pt 8):1793-1803
PubMed ID: 7551044