Pseudomonas aeruginosa PAO1, PA4100

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4100
Name
Replicon chromosome
Genomic location 4582852 - 4584531 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_252789.1
GI 15599295
Affymetrix PA4100_at
Entrez 878751
GenBank AAG07487.1
INSDC AAG07487.1
NCBI Locus Tag PA4100
protein_id(GenBank) gb|AAG07487.1|AE004826_5|gnl|PseudoCAP|PA4100
TIGR NTL03PA04100
UniParc UPI00000C5C0E
UniProtKB Acc Q9HWS8
UniProtKB ID Q9HWS8_PSEAE
UniRef100 UniRef100_Q9HWS8
UniRef50 UniRef50_Q4KBB1
UniRef90 UniRef90_V6A936

Product

Feature Type CDS
Coding Frame 1
Product Name
probable dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) 13.43
Kyte-Doolittle Hydrophobicity Value -0.164
Molecular Weight (kDa) 60.4
Isoelectric Point (pI) 9.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 216 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001590 (827 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4100

Human Homologs

Ensembl 110, assembly GRCh38.p14
choline dehydrogenase [Source:HGNC Symbol;Acc:HGNC:24288]
E-value: 2.6e-113
Percent Identity: 41.7

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
DNA sequence determination and functional characterization of the OCT-plasmid-encoded alkJKL genes of Pseudomonas oleovorans.
van Beilen JB, Eggink G, Enequist H, Bos R, Witholt B
Mol Microbiol 1992 Nov;6(21):3121-36
PubMed ID: 1453953
Cloning of genes coding for L-sorbose and L-sorbosone dehydrogenases from Gluconobacter oxydans and microbial production of 2-keto-L-gulonate, a precursor of L-ascorbic acid, in a recombinant G. oxydans strain.
Saito Y, Ishii Y, Hayashi H, Imao Y, Akashi T, Yoshikawa K, Noguchi Y, Soeda S, Yoshida M, Niwa M, Hosoda J, Shimomura K
Appl Environ Microbiol 1997 Feb;63(2):454-60
PubMed ID: 9023923