Pseudomonas aeruginosa PAO1, PA4108

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4108
Name
Replicon chromosome
Genomic location 4591187 - 4592431 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252797.1
GI 15599303
Affymetrix PA4108_at
Entrez 877982
GenBank AAG07495.1
INSDC AAG07495.1
NCBI Locus Tag PA4108
protein_id(GenBank) gb|AAG07495.1|AE004827_4|gnl|PseudoCAP|PA4108
TIGR NTL03PA04108
UniParc UPI00000C5C16
UniProtKB Acc Q9HWS0
UniProtKB ID Q9HWS0_PSEAE
UniRef100 UniRef100_Q9HWS0
UniRef50 UniRef50_Q9HWS0
UniRef90 UniRef90_Q9HWS0

Product

Feature Type CDS
Coding Frame 1
Product Name
cyclic di-GMP phosphodiesterase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 3.71
Kyte-Doolittle Hydrophobicity Value -0.014
Molecular Weight (kDa) 45.4
Isoelectric Point (pI) 7.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism Galleria mellonella
Notes
Infection model Galleria mellonella killing assay
Reference 19170727

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 339 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001589 (414 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4108

Human Homologs

References

HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa.
Ryan RP, Lucey J, O'Donovan K, McCarthy Y, Yang L, Tolker-Nielsen T, Dow JM
Environ Microbiol 2009 May;11(5):1126-36
PubMed ID: 19170727