Pseudomonas aeruginosa PAO1, PA4128

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4128
Name
Synonym: hpaI
Synonym: hpcH
Replicon chromosome
Genomic location 4616162 - 4616968 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252817.1
GI 15599323
Affymetrix PA4128_at
Entrez 881843
GenBank AAG07515.1
INSDC AAG07515.1
NCBI Locus Tag PA4128
protein_id(GenBank) gb|AAG07515.1|AE004829_5|gnl|PseudoCAP|PA4128
TIGR NTL03PA04128
UniParc UPI00000C5C25
UniProtKB Acc Q9HWQ3
UniProtKB ID Q9HWQ3_PSEAE
UniRef100 UniRef100_Q9HWQ3
UniRef50 UniRef50_Q8XE09
UniRef90 UniRef90_A6UZW5

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Charge (pH 7) -5.89
Kyte-Doolittle Hydrophobicity Value 0.104
Molecular Weight (kDa) 28.2
Isoelectric Point (pI) 5.10

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7V8T LYASE 08/23/21 Crystal structure of class II pyruvate aldolase from Pseudomonas aeruginosa. Pseudomonas aeruginosa 2.48 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 204 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001571 (401 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4128

Human Homologs

References

Sequence of the Escherichia coli C homoprotocatechuic acid degradative operon completed with that of the 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase-encoding gene (hpcH).
Stringfellow JM, Turpin B, Cooper RA
Gene 1995 Dec 1;166(1):73-6
PubMed ID: 8529896