Pseudomonas aeruginosa PAO1, PA4172

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4172
Name
Replicon chromosome
Genomic location 4668490 - 4669290 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252861.1
GI 15599367
Affymetrix PA4172_at
DNASU PaCD00007814
Entrez 880276
GenBank AAG07559.1
INSDC AAG07559.1
NCBI Locus Tag PA4172
protein_id(GenBank) gb|AAG07559.1|AE004833_10|gnl|PseudoCAP|PA4172
TIGR NTL03PA04172
UniParc UPI00000C5C51
UniProtKB Acc Q9HWK9
UniProtKB ID Q9HWK9_PSEAE
UniRef100 UniRef100_W0YYK7
UniRef50 UniRef50_A6UZS2
UniRef90 UniRef90_A6UZS2

Product

Feature Type CDS
Coding Frame 1
Product Name
probable nuclease
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -2.89
Kyte-Doolittle Hydrophobicity Value -0.425
Molecular Weight (kDa) 30.3
Isoelectric Point (pI) 6.43

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 522 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001526 (422 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4172
Search term: probable nuclease

Human Homologs

References

Nucleotide sequence of the xth gene of Escherichia coli K-12.
Saporito SM, Smith-White BJ, Cunningham RP
J Bacteriol 1988 Oct;170(10):4542-7
PubMed ID: 3049539
Structure and function of the multifunctional DNA-repair enzyme exonuclease III.
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA
Nature 1995 Mar 23;374(6520):381-6
PubMed ID: 7885481
Cleavage of single- and double-stranded DNAs containing an abasic residue by Escherichia coli exonuclease III (AP endonuclease VI).
Shida T, Noda M, Sekiguchi J
Nucleic Acids Res 1996 Nov 15;24(22):4572-6
PubMed ID: 8948651