Pseudomonas aeruginosa PAO1, PA0056 (osaR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0056
Name
osaR
Replicon chromosome
Genomic location 70702 - 71622 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 11 transposon mutants in orthologs

Cross-References

RefSeq NP_248746.1
GI 15595254
Affymetrix PA0056_at
DNASU PaCD00006024
Entrez 877984
GenBank AAG03446.1
INSDC AAG03446.1
NCBI Locus Tag PA0056
protein_id(GenBank) gb|AAG03446.1|AE004445_7|gnl|PseudoCAP|PA0056
TIGR NTL03PA00057
UniParc UPI00000C4F09
UniProtKB Acc Q9I776
UniProtKB ID Q9I776_PSEAE
UniRef100 UniRef100_A0A072ZH35
UniRef50 UniRef50_Q4K786
UniRef90 UniRef90_A6UXB7

Product

Feature Type CDS
Coding Frame 1
Product Name
OsaR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 0.08
Kyte-Doolittle Hydrophobicity Value -0.087
Molecular Weight (kDa) 33.6
Isoelectric Point (pI) 7.03

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 443 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000055 (3840 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0056
Search term: osaR
Search term: OsaR

Human Homologs

References

OsaR (PA0056) Functions as a Repressor of the Gene fleQ Encoding an Important Motility Regulator in Pseudomonas aeruginosa.
Ma Y, Liu Y, Bi Y, Han X, Jin Y, Xu H, Qiao M
J Bacteriol 2021 Sep 23;203(20):e0014521
PubMed ID: 34339300
Redox Protein OsaR (PA0056) Regulates dsbM and the Oxidative Stress Response in Pseudomonas aeruginosa.
Liu Y, Ma Y, Ma Z, Han X, Qi H, Andersen JB, Xu H, Tolker-Nielsen T, Qiao M
Antimicrob Agents Chemother 2021 Feb 17;65(3)
PubMed ID: 33361299