Pseudomonas aeruginosa PAO1, PA0178
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0178
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 202147 - 204066 (- strand) |
| Transposon Mutants | 3 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
Cross-References
| RefSeq | NP_248868.1 |
| GI | 15595376 |
| Affymetrix | PA0178_at |
| Entrez | 878420 |
| GenBank | AAG03568.1 |
| INSDC | AAG03568.1 |
| NCBI Locus Tag | PA0178 |
| protein_id(GenBank) | gb|AAG03568.1|AE004455_9|gnl|PseudoCAP|PA0178 |
| TIGR | NTL03PA00179 |
| UniParc | UPI00000C4F80 |
| UniProtKB Acc | Q9I6V4 |
| UniProtKB ID | Q9I6V4_PSEAE |
| UniRef100 | UniRef100_Q9I6V4 |
| UniRef50 | UniRef50_Q02UQ0 |
| UniRef90 | UniRef90_Q02UQ0 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
probable two-component sensor
|
| Synonyms |
probable chemotaxis protein sensory transduction histidine kinase |
| Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | -37.63 |
| Kyte-Doolittle Hydrophobicity Value | -0.121 |
| Molecular Weight (kDa) | 68.9 |
| Isoelectric Point (pI) | 4.52 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 399 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000176 (373 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0178
Search term: probable two-component sensor
|
Human Homologs
References
|
CheA protein, a central regulator of bacterial chemotaxis, belongs to a family of proteins that control gene expression in response to changing environmental conditions.
Stock A, Chen T, Welsh D, Stock J
Proc Natl Acad Sci U S A 1988 Mar;85(5):1403-7
PubMed ID: 3278311
|
|
Structure of CheA, a signal-transducing histidine kinase.
Bilwes AM, Alex LA, Crane BR, Simon MI
Cell 1999 Jan;96(1):131-41
PubMed ID: 9989504
|