Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA1180
|
Name |
phoQ
|
Replicon | chromosome |
Genomic location | 1278362 - 1279708 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | PhoP-PhoQ two-component regulatory system contributes to bacterial tolerance to polymyxin B by directly regulating genes involved in LPS modification and membrane integrity maintenance[PMID:33572426] |
RefSeq | NP_249871.1 |
GI | 15596377 |
Affymetrix | PA1180_phoQ_at |
Entrez | 879187 |
GenBank | AAG04569.1 |
INSDC | AAG04569.1 |
NCBI Locus Tag | PA1180 |
protein_id(GenBank) | gb|AAG04569.1|AE004548_3|gnl|PseudoCAP|PA1180 |
TIGR | NTL03PA01181 |
UniParc | UPI00000C5291 |
UniProtKB Acc | Q9I4F8 |
UniProtKB ID | Q9I4F8_PSEAE |
UniRef100 | UniRef100_Q9I4F8 |
UniRef50 | UniRef50_Q4K876 |
UniRef90 | UniRef90_Q9I4F8 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
two-component sensor PhoQ
|
Synonyms | |
Evidence for Translation |
Detected using LC-MS/MS (50.28 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -4.90 |
Kyte-Doolittle Hydrophobicity Value | -0.204 |
Molecular Weight (kDa) | 50.2 |
Isoelectric Point (pI) | 6.09 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | Lactuca sativa |
Notes | |
Infection model | Lettuce Infection model |
Reference | 19246741 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 601 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001138 (522 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA1180
Search term: phoQ
Search term: two-component sensor PhoQ
|
A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.
Miller SI, Kukral AM, Mekalanos JJ
Proc Natl Acad Sci U S A 1989 Jul;86(13):5054-8
PubMed ID: 2544889
|
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
|
PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients.
Miller AK, Brannon MK, Stevens L, Johansen HK, Selgrade SE, Miller SI, Høiby N, Moskowitz SM
Antimicrob Agents Chemother 2011 Dec;55(12):5761-9
PubMed ID: 21968359
|
Identification of Novel PhoP-PhoQ Regulated Genes That Contribute to Polymyxin B Tolerance in Pseudomonas aeruginosa.
Yang B, Liu C, Pan X, Fu W, Fan Z, Jin Y, Bai F, Cheng Z, Wu W
Microorganisms 2021 Feb 9;9(2)
PubMed ID: 33572426
|