Pseudomonas aeruginosa PAO1, PA1244 (qslA)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
Locus Tag
Replicon chromosome
Genomic location 1348060 - 1348401 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
CommentStart site updated to 1348063 based on purified QslA_FLAG fusion protein analysis by Edman degradation (PMID:213921320).


RefSeq NP_249935.1
GI 15596441
Affymetrix PA1244_at
DNASU PaCD00006576
Entrez 881242
GenBank AAG04633.1
INSDC AAG04633.1
NCBI Locus Tag PA1244
protein_id(GenBank) gb|AAG04633.1|AE004554_1|gnl|PseudoCAP|PA1244
UniParc UPI00000C52CD
UniProtKB Acc Q9I494
UniRef100 UniRef100_Q9I494
UniRef50 UniRef50_Q9I494
UniRef90 UniRef90_Q9I494


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 1
Synonyms LasR-specific antiactivator QslA
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.23
Kyte-Doolittle Hydrophobicity Value -0.426
Molecular Weight (kDa) 11.8
Isoelectric Point (pI) 7.54

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4NG2 Transcription Regulator 11/01/13 Crystal structure of LasR LBD-QslA complex from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.413 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001196 (298 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA1244
Search term: qslA
Search term: QslA

Human Homologs


Differential Modulation of Quorum Sensing Signaling through QslA in Pseudomonas aeruginosa Strains PAO1 and PA14.
Sana TG, Lomas R, Gimenez MR, Laubier A, Soscia C, Chauvet C, Conesa A, Voulhoux R, Ize B, Bleves S
J Bacteriol 2019 Nov 1;201(21)
PubMed ID: 31405911
Anti-activator QslA defines the quorum sensing threshold and response in Pseudomonas aeruginosa.
Seet Q, Zhang LH
Mol Microbiol 2011 May;80(4):951-65
PubMed ID: 21392132
QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing.
Fan H, Dong Y, Wu D, Bowler MW, Zhang L, Song H
Proc Natl Acad Sci U S A 2013 Dec 17;110(51):20765-70
PubMed ID: 24319092