Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA1244
|
Name |
qslA
|
Replicon | chromosome |
Genomic location | 1348060 - 1348401 (- strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Comment | Start site updated to 1348063 based on purified QslA_FLAG fusion protein analysis by Edman degradation (PMID:213921320). |
RefSeq | NP_249935.1 |
GI | 15596441 |
Affymetrix | PA1244_at |
DNASU | PaCD00006576 |
Entrez | 881242 |
GenBank | AAG04633.1 |
INSDC | AAG04633.1 |
NCBI Locus Tag | PA1244 |
protein_id(GenBank) | gb|AAG04633.1|AE004554_1|gnl|PseudoCAP|PA1244 |
TIGR | NTL03PA01245 |
UniParc | UPI00000C52CD |
UniProtKB Acc | Q9I494 |
UniProtKB ID | Q9I494_PSEAE |
UniRef100 | UniRef100_Q9I494 |
UniRef50 | UniRef50_Q9I494 |
UniRef90 | UniRef90_Q9I494 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
QslA
|
Synonyms |
LasR-specific antiactivator QslA |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | 0.23 |
Kyte-Doolittle Hydrophobicity Value | -0.426 |
Molecular Weight (kDa) | 11.8 |
Isoelectric Point (pI) | 7.54 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
4NG2 | Transcription Regulator | 11/01/13 | Crystal structure of LasR LBD-QslA complex from Pseudomonas aeruginosa | Pseudomonas aeruginosa | 2.413 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in one genus
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001196 (298 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA1244
Search term: qslA
Search term: QslA
|
Differential Modulation of Quorum Sensing Signaling through QslA in Pseudomonas aeruginosa Strains PAO1 and PA14.
Sana TG, Lomas R, Gimenez MR, Laubier A, Soscia C, Chauvet C, Conesa A, Voulhoux R, Ize B, Bleves S
J Bacteriol 2019 Nov 1;201(21)
PubMed ID: 31405911
|
Anti-activator QslA defines the quorum sensing threshold and response in Pseudomonas aeruginosa.
Seet Q, Zhang LH
Mol Microbiol 2011 May;80(4):951-65
PubMed ID: 21392132
|
QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing.
Fan H, Dong Y, Wu D, Bowler MW, Zhang L, Song H
Proc Natl Acad Sci U S A 2013 Dec 17;110(51):20765-70
PubMed ID: 24319092
|