Pseudomonas aeruginosa PAO1, PA2367 (hcp3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA2367
Name
hcp3
Replicon chromosome
Genomic location 2617019 - 2617516 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251057.1
GI 15597563
Affymetrix PA2367_at
Entrez 881890
GenBank AAG05755.1
INSDC AAG05755.1
NCBI Locus Tag PA2367
protein_id(GenBank) gb|AAG05755.1|AE004663_1|gnl|PseudoCAP|PA2367
TIGR NTL03PA02367
UniParc UPI00000C5693
UniProtKB Acc Q9I1B2
UniProtKB ID Q9I1B2_PSEAE
UniRef100 UniRef100_W0YU48
UniRef50 UniRef50_D2TPU7
UniRef90 UniRef90_W0YU48

Product

Feature Type CDS
Coding Frame 1
Product Name
Hcp3
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.59
Kyte-Doolittle Hydrophobicity Value -0.142
Molecular Weight (kDa) 17.6
Isoelectric Point (pI) 4.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-3 encoded type VI secretion system (H3-T6SS)
Evidence ECO:0000317
genomic context evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes
Infection model Caenorhabditis elegans slow killing assay. H3-T6SS rendered inactive via clpV3 deletion.
Reference 24204589

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 70 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000084 (770 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2367
Search term: hcp3
Search term: Hcp3

Human Homologs

References

A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ
Science 2006 Jun;312(5779):1526-30
PubMed ID: 16763151
Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa.
Sana TG, Soscia C, Tonglet CM, Garvis S, Bleves S
PLoS ONE 2013 ;8(10):e76030
PubMed ID: 24204589