Pseudomonas aeruginosa PAO1, PA3139

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3139
Name
Synonym: aspC
Synonym: tyrB
Replicon chromosome
Genomic location 3522748 - 3523944 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251829.1
GI 15598335
Affymetrix PA3139_at
Entrez 882671
GenBank AAG06527.1
INSDC CAA63758.1
NCBI Locus Tag PA3139
protein_id(GenBank) gb|AAG06527.1|AE004738_1|gnl|PseudoCAP|PA3139
TIGR NTL03PA03139
UniParc UPI00001250EA
UniProtKB Acc P72173
UniProtKB ID AAT_PSEAE
UniRef100 UniRef100_P72173
UniRef50 UniRef50_O85746
UniRef90 UniRef90_P72173

Product

Feature Type CDS
Coding Frame 1
Product Name
probable amino acid aminotransferase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.40
Kyte-Doolittle Hydrophobicity Value -0.060
Molecular Weight (kDa) 43.3
Isoelectric Point (pI) 6.64

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 168 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002461 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3139

Human Homologs

Ensembl 110, assembly GRCh38.p14
glutamic-oxaloacetic transaminase 2 [Source:HGNC Symbol;Acc:HGNC:4433]
E-value: 7.4e-91
Percent Identity: 43.5

References

The cloning and sequence analysis of the aspC and tyrB genes from Escherichia coli K12. Comparison of the primary structures of the aspartate aminotransferase and aromatic aminotransferase of E. coli with those of the pig aspartate aminotransferase isoenzymes.
Fotheringham IG, Dacey SA, Taylor PP, Smith TJ, Hunter MG, Finlay ME, Primrose SB, Parker DM, Edwards RM
Biochem J 1986 Mar 15;234(3):593-604
PubMed ID: 3521591
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994