Pseudomonas aeruginosa PAO1, PA3165 (hisC2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3165
Name
hisC2
Replicon chromosome
Genomic location 3552979 - 3554088 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251855.1
GI 15598361
Affymetrix PA3165_hisC2_at
DNASU PaCD00007392
Entrez 882694
GenBank AAG06553.1
INSDC AAG06553.1
NCBI Locus Tag PA3165
protein_id(GenBank) gb|AAG06553.1|AE004740_6|gnl|PseudoCAP|PA3165
TIGR NTL03PA03165
UniParc UPI000012C70F
UniProtKB Acc Q9HZ68
UniProtKB ID HIS82_PSEAE
UniRef100 UniRef100_Q9HZ68
UniRef50 UniRef50_O07131
UniRef90 UniRef90_Q9HZ68

Product

Feature Type CDS
Coding Frame 1
Product Name
histidinol-phosphate aminotransferase
Product Name Confidence: Class 2
Synonyms imidazole acetol-phosphate transaminase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -10.61
Kyte-Doolittle Hydrophobicity Value 0.058
Molecular Weight (kDa) 39.5
Isoelectric Point (pI) 4.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 630 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002450 (463 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3165
Search term: hisC2

Human Homologs

References

The organization and nucleotide sequence of the Bacillus subtilis hisH, tyrA and aroE genes.
Henner DJ, Band L, Flaggs G, Chen E
Gene 1986;49(1):147-52
PubMed ID: 3106153
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.
Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM
Science 1995 Jul 28;269(5223):496-512
PubMed ID: 7542800
A probable mixed-function supraoperon in Pseudomonas exhibits gene organization features of both intergenomic conservation and gene shuffling.
Xie G, Bonner CA, Jensen RA
J Mol Evol 1999 Jul;49(1):108-21
PubMed ID: 10368439