Pseudomonas aeruginosa PAO1, PA3790 (oprC)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 4247703 - 4249874 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentLocalication to outer membrane vesicle confirmed in three separate studies (PMID:22909304, PMID:21751344 and PMID:26303878).


RefSeq NP_252479.1
GI 15598985
Affymetrix PA3790_oprC_at
Entrez 879091
GenBank AAG07177.1
INSDC AAG07177.1
NCBI Locus Tag PA3790
protein_id(GenBank) gb|AAG07177.1|AE004797_12|gnl|PseudoCAP|PA3790
UniParc UPI00000D428D
UniProtKB Acc G3XD89
UniRef100 UniRef100_Q02RU4
UniRef50 UniRef50_Q88DI7
UniRef90 UniRef90_Q02RU4


Feature Type CDS
Coding Frame 1
Product Name
Putative copper transport outer membrane porin OprC precursor
Product Name Confidence: Class 1
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Detected using LC-MS/MS (79.30 kDa, PMID:21751344)
Charge (pH 7) -4.17
Kyte-Doolittle Hydrophobicity Value -0.494
Molecular Weight (kDa) 79.3
Isoelectric Point (pI) 6.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 1
Outer Membrane Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6FOK MEMBRANE PROTEIN 02/07/18 Copper transporter OprC PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.97 X-RAY DIFFRACTION 100.0
6FOM MEMBRANE PROTEIN 02/07/18 Copper transporter OprC PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.9 X-RAY DIFFRACTION 99.7

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 197 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001876 (509 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA3790
Search term: oprC

Human Homologs


Identification of porins in the outer membrane of Pseudomonas aeruginosa that form small diffusion pores.
Yoshihara E, Nakae T
J Biol Chem 1989 Apr 15;264(11):6297-301
PubMed ID: 2539376
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
Identification of proteins associated with the Pseudomonas aeruginosa biofilm extracellular matrix.
Toyofuku M, Roschitzki B, Riedel K, Eberl L
J Proteome Res 2012 Oct 5;11(10):4906-15
PubMed ID: 22909304
Proteome Profiles of Outer Membrane Vesicles and Extracellular Matrix of Pseudomonas aeruginosa Biofilms.
Couto N, Schooling SR, Dutcher JR, Barber J
J Proteome Res 2015 Oct 2;14(10):4207-22
PubMed ID: 26303878