Pseudomonas aeruginosa PAO1, PA3792 (leuA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA3792
Name
leuA
Replicon chromosome
Genomic location 4250828 - 4252606 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252481.3
GI 161486762
Affymetrix PA3792_leuA_at
Entrez 879941
GenBank AAG07179.1
INSDC AAG07179.1
NCBI Locus Tag PA3792
protein_id(GenBank) gb|AAG07179.1|AE004798_2|gnl|PseudoCAP|PA3792
TIGR NTL03PA03792
UniParc UPI000012E4CC
UniProtKB Acc Q9HXK5
UniProtKB ID LEU1_PSEAE
UniRef100 UniRef100_Q9HXK5
UniRef50 UniRef50_Q9HXK5
UniRef90 UniRef90_Q9HXK5

Product

Feature Type CDS
Coding Frame 1
Product Name
2-isopropylmalate synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -13.27
Kyte-Doolittle Hydrophobicity Value -0.271
Molecular Weight (kDa) 65.8
Isoelectric Point (pI) 5.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 573 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001874 (551 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3792
Search term: leuA

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Leucine synthesis in Corynebacterium glutamicum: enzyme activities, structure of leuA, and effect of leuA inactivation on lysine synthesis.
Pátek M, Krumbach K, Eggeling L, Sahm H
Appl. Environ. Microbiol. 1994 Jan;60(1):133-40
PubMed ID: 8117072