Pseudomonas aeruginosa PAO1, PA5266 (vgrG6)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5266
Name
vgrG6
Replicon chromosome
Genomic location 5930602 - 5932677 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 10 transposon mutants in orthologs

Cross-References

RefSeq NP_253953.1
GI 15600459
Affymetrix PA5266_at
Entrez 879578
GenBank AAG08651.1
INSDC AAG08651.1
NCBI Locus Tag PA5266
protein_id(GenBank) gb|AAG08651.1|AE004939_3|gnl|PseudoCAP|PA5266
TIGR NTL03PA05267
UniParc UPI00000C5F7C
UniProtKB Acc Q9HTT3
UniProtKB ID Q9HTT3_PSEAE
UniRef100 UniRef100_Q9HTT3
UniRef50 UniRef50_G8Q3S5
UniRef90 UniRef90_Q9HTT3

Product

Feature Type CDS
Coding Frame 1
Product Name
VgrG6
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -9.16
Kyte-Doolittle Hydrophobicity Value -0.499
Molecular Weight (kDa) 76.7
Isoelectric Point (pI) 6.43

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 145 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000090 (3342 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5266
Search term: vgrG6
Search term: VgrG6

Human Homologs

References

Rhs elements comprise three subfamilies which diverged prior to acquisition by Escherichia coli.
Wang YD, Zhao S, Hill CW
J Bacteriol 1998 Aug;180(16):4102-10
PubMed ID: 9696756
Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins.
Hachani A, Lossi NS, Hamilton A, Jones C, Bleves S, Albesa-Jové D, Filloux A
J Biol Chem 2011 Apr 8;286(14):12317-27
PubMed ID: 21325275