Pseudomonas aeruginosa UCBPP-PA14, PA14_01150 (eagT6)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
Locus Tag
Replicon chromosome
Genomic location 112593 - 113027 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
CommentHcp Secretion Island-I-encoded type VI secretion system (H1-T6SS)


RefSeq YP_788252.1
GI 116053815
Entrez 4383513
INSDC ABJ15051.1
NCBI Locus Tag PA14_01150
UniParc UPI00000C4F2F
UniProtKB Acc Q02UY4
UniRef100 UniRef100_W0YKR3
UniRef50 UniRef50_Q4K3M6
UniRef90 UniRef90_A6UXM9


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -0.57
Kyte-Doolittle Hydrophobicity Value -0.464
Molecular Weight (kDa) 16.5
Isoelectric Point (pI) 6.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6XRF CHAPERONE 07/12/20 EagT6 Tse6 NT complex Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.56 X-RAY DIFFRACTION 100.0
1TU1 STRUCTURAL GENOMICS, UNKNOWN FUNCTION 06/24/04 Crystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative Regulator Pseudomonas aeruginosa 1.95 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 13 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000093 (310 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA14_01150
Search term: eagT6
Search term: EagT6

Human Homologs


An interbacterial NAD(P)(+) glycohydrolase toxin requires elongation factor Tu for delivery to target cells.
Whitney JC, Quentin D, Sawai S, LeRoux M, Harding BN, Ledvina HE, Tran BQ, Robinson H, Goo YA, Goodlett DR, Raunser S, Mougous JD
Cell 2015 Oct 22;163(3):607-19
PubMed ID: 26456113
RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999