Pseudomonas aeruginosa UCBPP-PA14, PA14_42890 (stp1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_42890
Name
stp1
Replicon chromosome
Genomic location 3811486 - 3812214 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq YP_791576.1
GI 116049619
Entrez 4382932
INSDC ABJ10855.1
NCBI Locus Tag PA14_42890
UniParc UPI00003967F2
UniProtKB Acc Q02KG0
UniProtKB ID Q02KG0_PSEAB
UniRef100 UniRef100_Q02KG0
UniRef50 UniRef50_G0ERT8
UniRef90 UniRef90_Q02KG0

Product

Feature Type CDS
Coding Frame 1
Product Name
Stp1
Product Name Confidence: Class 1
Synonyms serine/threonine phosphoprotein phosphatase Stp1
Evidence for Translation
Charge (pH 7) -2.19
Kyte-Doolittle Hydrophobicity Value -0.187
Molecular Weight (kDa) 26.8
Isoelectric Point (pI) 6.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-2 encoded type VI secretion system (H2-T6SS)
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse acute lung Infection model
Infection model Mouse burn Infection model
Reference 19497948
Source 2
Database PseudoCAP
Category Hcp secretion island-2 encoded type VI secretion system (H2-T6SS)
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration model
Reference 19497948

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 398 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000074 (811 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_42890
Search term: stp1
Search term: Stp1

Human Homologs

References

Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis.
Lesic B, Starkey M, He J, Hazan R, Rahme LG
Microbiology (Reading) 2009 Sep;155(Pt 9):2845-2855
PubMed ID: 19497948
The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells.
Sana TG, Hachani A, Bucior I, Soscia C, Garvis S, Termine E, Engel J, Filloux A, Bleves S
J Biol Chem 2012 Aug 3;287(32):27095-105
PubMed ID: 22665491