Pseudomonas aeruginosa UCBPP-PA14, PA14_48150 (qslA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_48150
Name
qslA
Replicon chromosome
Genomic location 4286195 - 4286536 (+ strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_792001.1
GI 116049197
Entrez 4385538
INSDC ABJ10433.1
NCBI Locus Tag PA14_48150
UniParc UPI00000C52CD
UniProtKB Acc Q02J85
UniProtKB ID Q02J85_PSEAB
UniRef100 UniRef100_Q9I494
UniRef50 UniRef50_Q9I494
UniRef90 UniRef90_Q9I494

Product

Feature Type CDS
Coding Frame 1
Product Name
QslA
Product Name Confidence: Class 1
Synonyms LasR-specific antiactivator QslA
Evidence for Translation
Charge (pH 7) 1.23
Kyte-Doolittle Hydrophobicity Value -0.386
Molecular Weight (kDa) 12.7
Isoelectric Point (pI) 9.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4NG2 Transcription Regulator 11/01/13 Crystal structure of LasR LBD-QslA complex from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.413 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001196 (298 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_48150
Search term: qslA
Search term: QslA

Human Homologs

References

Differential Modulation of Quorum Sensing Signaling through QslA in Pseudomonas aeruginosa Strains PAO1 and PA14.
Sana TG, Lomas R, Gimenez MR, Laubier A, Soscia C, Chauvet C, Conesa A, Voulhoux R, Ize B, Bleves S
J Bacteriol 2019 Nov 1;201(21)
PubMed ID: 31405911
QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing.
Fan H, Dong Y, Wu D, Bowler MW, Zhang L, Song H
Proc Natl Acad Sci U S A 2013 Dec 17;110(51):20765-70
PubMed ID: 24319092