Pseudomonas aeruginosa UCBPP-PA14, PA14_49460 (nrdA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_49460
Name
nrdA
Replicon chromosome
Genomic location 4394703 - 4397594 (+ strand)

Cross-References

RefSeq YP_792110.1
GI 116049088
EC Number 1.17.4.1
Entrez 4381686
INSDC ABJ10324.1
NCBI Locus Tag PA14_49460
UniParc UPI00000C527A
UniProtKB Acc Q02IX6
UniProtKB ID Q02IX6_PSEAB
UniRef100 UniRef100_W0YQ69
UniRef50 UniRef50_Q607W9
UniRef90 UniRef90_A4VK21

Product

Feature Type CDS
Coding Frame 1
Product Name
ribonucleotide-diphosphate reductase subunit alpha
Synonyms
Evidence for Translation
Charge (pH 7) -14.68
Kyte-Doolittle Hydrophobicity Value -0.309
Molecular Weight (kDa) 107.1
Isoelectric Point (pI) 5.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5IM3 OXIDOREDUCTASE 03/05/16 Crystal structure of the class I ribonucleotide reductase from Pseudomonas aeruginosa in complex with dATP Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 2.298 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 603 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001115 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_49460
Search term: nrdA

Human Homologs

Ensembl 110, assembly GRCh38.p14
ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451]
E-value: 2.9e-157
Percent Identity: 41.0

References

No references are associated with this feature.