Pseudomonas aeruginosa UCBPP-PA14, PA14_50220 (fleQ)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_50220
Name	fleQ
Replicon	chromosome
Genomic location	4460872 - 4462344 (- strand)
Transposon Mutants	2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	YP_792172.1
GI	116049026
Entrez	4380062
INSDC	ABJ10262.1
NCBI Locus Tag	PA14_50220
UniParc	UPI00000D421B
UniProtKB Acc	Q02IR4
UniProtKB ID	Q02IR4_PSEAB
UniRef100	UniRef100_G3XCV0
UniRef50	UniRef50_G3XCV0
UniRef90	UniRef90_G3XCV0

Product

Feature Type	CDS
Coding Frame	1
Product Name	transcriptional regulator FleQ
Synonyms
Evidence for Translation
Charge (pH 7)	-13.91
Kyte-Doolittle Hydrophobicity Value	-0.364
Molecular Weight (kDa)	55.3
Isoelectric Point (pI)	5.03

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6JDL	TRANSCRIPTION	02/01/19	Central domain of FleQ H287A mutant in complex with ATPgS and Mg	Pseudomonas aeruginosa	2.249	X-RAY DIFFRACTION	99.2
7EJW	TRANSCRIPTION	04/02/21	Crystal structure of FleN in complex with FleQ AAA+ doamain	Pseudomonas aeruginosa PAO1	1.98	X-RAY DIFFRACTION	99.6
4WXM	TRANSCRIPTION REGULATOR	11/14/14	FleQ REC domain from Pseudomonas aeruginosa PAO1	Pseudomonas aeruginosa PAO1	2.3	X-RAY DIFFRACTION	100.0
6J7E	TRANSCRIPTION	01/18/19	Crystal Structure of Central domain of FleQ in complex with ATPgS and Mg	Pseudomonas aeruginosa	2.4	X-RAY DIFFRACTION	99.6
5EXX	TRANSCRIPTION	11/24/15	AAA+ ATPase FleQ from Pseudomonas aeruginosa bound to c-di-GMP	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)	3.311	X-RAY DIFFRACTION	100.0
6JDI	TRANSCRIPTION	02/01/19	Central domain of FleQ H287N mutant in complex with ATPgS and Mg	Pseudomonas aeruginosa	1.95	X-RAY DIFFRACTION	99.2
5EXP	TRANSCRIPTION	11/24/15	AAA+ domain of FleQ from Pseudomonas aeruginosa	Pseudomonas aeruginosa	1.8	X-RAY DIFFRACTION	100.0
5EXS	TRANSCRIPTION	11/24/15	AAA+ ATPase FleQ from Pseudomonas aeruginosa bound to ATP-gamma-S	Pseudomonas aeruginosa	2.5	X-RAY DIFFRACTION	100.0
5EXT	TRANSCRIPTION	11/24/15	AAA+ domain of FleQ from Pseudomonas aeruginosa bound to ADP	Pseudomonas aeruginosa	2.4	X-RAY DIFFRACTION	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 453 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001058 (532 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_50220 Search term: fleQ Search term: transcriptional regulator FleQ

Human Homologs

References