Pseudomonas aeruginosa PAO1, PA2492 (mexT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA2492
Name
mexT
Replicon chromosome
Genomic location 2807469 - 2808512 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs
CommentContains an 8_bp insertion at 2807703-2807710 which is the result of a duplication of the preceding 8_bp GGCCAGCC sequence at 2807695-2807702. When translated from this start codon, premature termination occurs at 2807857-2807859 and a MexT polypeptide of 89 amino acids is encoded (PMID:31859619).
Comment PAO1 strains containing the 8_bp insertion are unable to express MexEF-OprN due to a non-functional MexT(PMID: 11040437)

Cross-References

RefSeq
GI
Affymetrix PA2492_mexT_at
Entrez 880417
GenBank AAG05880.1
NCBI Locus Tag PA2492
protein_id(GenBank) gb|AAG05880.1|AE004676_12|gnl|PseudoCAP|PA2492
TIGR NTL03PA02492
UniProtKB Acc Q9I0Z0
UniProtKB ID Q9I0Z0_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator MexT
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)
Kyte-Doolittle Hydrophobicity Value
Molecular Weight (kDa)
Isoelectric Point (pI)

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 185 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001179 (1988 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2492
Search term: mexT

Human Homologs

References

Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa.
Köhler T, Michéa-Hamzehpour M, Henze U, Gotoh N, Curty LK, Pechère JC
Mol. Microbiol. 1997 Jan;23(2):345-54
PubMed ID: 9044268
MexT regulates the type III secretion system through MexS and PtrC in Pseudomonas aeruginosa.
Jin Y, Yang H, Qiao M, Jin S
J. Bacteriol. 2011 Jan;193(2):399-410
PubMed ID: 21075931
<i>Pseudomonas aeruginosa mexT</i> is an indicator of PAO1 strain integrity.
LoVullo ED, Schweizer HP
J Med Microbiol 2020 Jan;69(1):139-145
PubMed ID: 31859619
Variation of the mexT gene, a regulator of the MexEF-oprN efflux pump expression in wild-type strains of Pseudomonas aeruginosa.
Maseda H, Saito K, Nakajima A, Nakae T
FEMS Microbiol Lett 2000 Nov 1;192(1):107-12
PubMed ID: 11040437