GEO Dataset
| GEO Dataset | Dataset details |
| GDS ID | 200037664 |
| GDS Accession | GSE37664 |
| Title | Human cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 1A) |
| Summary | Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an animal model of MS to explore the role of the identified lipids in autoimmune demyelination. We found that autoantibodies in MS target a phosphate group in phosphatidylserine and oxidized phosphatidylcholine derivatives. Administration of these lipids ameliorated experimental autoimmune encephalomyelitis by suppressing activation and inducing apoptosis of autoreactive T cells, effects mediated by the lipids' saturated fatty-acid side chains. Thus, phospholipids represent a natural anti-inflammatory class of compounds that have potential as novel therapeutics for MS. |
| Expression Profiles | 0 |
| Number of Samples | 59 |
| GEO Series | GSE37664 |
| Reference | PMID:22674551 |
| GDS Data Type | Other |
| Taxon | Bacillus subtilis; Salmonella enterica subsp. enterica serovar Typhimurium; Streptococcus pyogenes; Bos primigenius; Pseudomonas aeruginosa; Mycobacterium tuberculosis; Homo sapiens; Escherichia coli; Staphylococcus aureus; Sus scrofa domesticus |
Platforms
| Name | SUWHR Lipids 104 v1.0 |
| Technology Type | other |
| Accession | GPL15505 |