Strain |
Pseudomonas aeruginosa PA7
GCF_000017205.1|latest |
Locus Tag |
PSPA7_2375
|
Name |
pumA
|
Replicon | chromosome |
Genomic location | 2420133 - 2421044 (+ strand) |
Comment | P. aeruginosa strain UCBPP-PA14 PA14_35160 was named pumA in PMID:29629858 (2018), however P. aeruginosa PA7 gene PSPA7_2375 was named pumA a year earlier in PMID:28483816 (2017). The earlier PA7 paper takes precedence for using pumA as primary gene name. |
RefSeq | YP_001347742.1 |
GI | 152988748 |
Entrez | 5358979 |
INSDC | ABR85931.1 |
NCBI Locus Tag | PSPA7_2375 |
UniParc | UPI000157754F |
UniProtKB Acc | A6V3V7 |
UniProtKB ID | A6V3V7_PSEA7 |
UniRef100 | UniRef100_A6V3V7 |
UniRef50 | UniRef50_A6V3V7 |
UniRef90 | UniRef90_A6V3V7 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
PumA
|
Synonyms |
hypothetical protein |
Evidence for Translation | |
Charge (pH 7) | -9.18 |
Kyte-Doolittle Hydrophobicity Value | -0.296 |
Molecular Weight (kDa) | 34642.3 |
Isoelectric Point (pI) | 4.85 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Mus musculus |
Notes | PA7 pumA mutant-infected mice showed decreased cell recruitment and an enhanced lung bacterial clearance in bronchoalveolar lavages compared to the wild-type strain. |
Infection model | Mouse pulmonary infection model |
Reference | 28483816 |
Source 2 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Homo sapiens |
Notes | PumA is essential for control of NF-?B translocation into the nucleus during Pseudomonas aeruginosa infection of human A549 lung epithelial cells |
Infection model | Infection of human A549 lung carcinoma epithelial cells |
Reference | 28483816 |
Source 3 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Caenorhabditis elegans |
Notes | PA7 wild-type strain caused 50% lethality 7 days after inoculation while PA7 pumA mutant showed a slight but significant attenuation in virulence in C. elegans. |
Infection model | C. elegans slow killing assay. |
Reference | 28483816 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 56 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG024070 (9 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PSPA7_2375
Search term: pumA
Search term: PumA
|
A Pseudomonas aeruginosa TIR effector mediates immune evasion by targeting UBAP1 and TLR adaptors.
Imbert PR, Louche A, Luizet JB, Grandjean T, Bigot S, Wood TE, Gagné S, Blanco A, Wunderley L, Terradot L, Woodman P, Garvis S, Filloux A, Guery B, Salcedo SP
EMBO J 2017 Jul 3;36(13):1869-1887
PubMed ID: 28483816
|