Pseudomonas aeruginosa UCBPP-PA14, PA14_04480 (thyA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_04480
Name
thyA
Replicon chromosome
Genomic location 398905 - 399699 (+ strand)

Cross-References

RefSeq YP_788513.1
GI 116054070
EC Number 2.1.1.45
Entrez 4383748
INSDC ABJ15306.1
NCBI Locus Tag PA14_04480
UniParc UPI00001378E8
UniProtKB Acc Q02U73
UniProtKB ID TYSY_PSEAB
UniRef100 UniRef100_B7V2Q5
UniRef50 UniRef50_Q12CI6
UniRef90 UniRef90_A6UYE6

Product

Feature Type CDS
Coding Frame 1
Product Name
thymidylate synthase
Synonyms
Evidence for Translation
Charge (pH 7) -3.24
Kyte-Doolittle Hydrophobicity Value -0.154
Molecular Weight (kDa) 30.0
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 401 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000334 (395 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_04480
Search term: thyA

Human Homologs

Ensembl 110, assembly GRCh38.p14
thymidylate synthetase [Source:HGNC Symbol;Acc:HGNC:12441]
E-value: 3.9e-80
Percent Identity: 51.4

References

No references are associated with this feature.