Pseudomonas aeruginosa UCBPP-PA14, PA14_25660 (fabG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_25660
Name
fabG
Replicon chromosome
Genomic location 2243222 - 2243965 (+ strand)

Cross-References

RefSeq YP_790206.1
GI 116050969
EC Number 1.1.1.100
Entrez 4384348
INSDC ABJ12205.1
NCBI Locus Tag PA14_25660
UniParc UPI000012A462
UniProtKB Acc Q02PD0
UniProtKB ID Q02PD0_PSEAB
UniRef100 UniRef100_O54438
UniRef50 UniRef50_P0AEK2
UniRef90 UniRef90_O54438

Product

Feature Type CDS
Coding Frame 1
Product Name
3-ketoacyl-ACP reductase
Synonyms
Evidence for Translation
Charge (pH 7) -0.52
Kyte-Doolittle Hydrophobicity Value 0.176
Molecular Weight (kDa) 25.6
Isoelectric Point (pI) 6.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4BO7 OXIDOREDUCTASE 05/18/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution PSEUDOMONAS AERUGINOSA 2.6 X-RAY DIFFRACTION 100.0
4BO6 OXIDOREDUCTASE 05/18/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2,3-dihydroindol-1-yl-(2- thiophen-3-yl-1,3-thiazol-4-yl)methanone at 2.8A resolution PSEUDOMONAS AERUGINOSA 2.8 X-RAY DIFFRACTION 100.0
4BO2 OXIDOREDUCTASE 05/18/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(1-ethylbenzimidazol-2- yl)-3-(2-methoxyphenyl)urea at 1.9A resolution PSEUDOMONAS AERUGINOSA 1.9 X-RAY DIFFRACTION 100.0
4BO0 OXIDOREDUCTASE 05/17/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(4-methoxy-1- methylindazol-3-yl)-3-(2-methoxyphenyl)urea at 2.4A resolution PSEUDOMONAS AERUGINOSA 2.4 X-RAY DIFFRACTION 100.0
4BO1 OXIDOREDUCTASE 05/18/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(4-chloro-2,5- dimethoxyphenyl)quinoline-8-carboxamide at 2.2A resolution PSEUDOMONAS AERUGINOSA 2.2 X-RAY DIFFRACTION 100.0
4BO3 OXIDOREDUCTASE 05/18/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2-(3-(trifluoromethyl) anilino)pyridine-3-sulfonamide at 2.5A resolution PSEUDOMONAS AERUGINOSA 2.5 X-RAY DIFFRACTION 100.0
4BO9 OXIDOREDUCTASE 05/18/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 5-(2-(furan-2-ylmethoxy) phenyl)-2-phenyltetrazole at 2.9A resolution PSEUDOMONAS AERUGINOSA 2.9 X-RAY DIFFRACTION 100.0
4BO8 OXIDOREDUCTASE 05/18/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(2-amino-4- phenylimidazol-1-yl)-3-(2-fluorophenyl)urea at 2.7A resolution PSEUDOMONAS AERUGINOSA 2.7 X-RAY DIFFRACTION 100.0
4BNY OXIDOREDUCTASE 05/17/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 4-(2-phenylthieno(3,2-d) pyrimidin-4-yl)morpholine at 1.8A resolution PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 100.0
4BNZ OXIDOREDUCTASE 05/17/13 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-methyl-N-phenylindole- 3-carboxamide at 2.5A resolution PSEUDOMONAS AERUGINOSA 2.5 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 652 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002615 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_25660
Search term: fabG

Human Homologs

Ensembl 110, assembly GRCh38.p14
carbonyl reductase 4 [Source:HGNC Symbol;Acc:HGNC:25891]
E-value: 4.4e-41
Percent Identity: 42.7

References

No references are associated with this feature.