Pseudomonas aeruginosa UCBPP-PA14, PA14_27460 (tpm)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_27460
Name	tpm
Replicon	chromosome
Genomic location	2383567 - 2384223 (+ strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	YP_790341.1
GI	116050836
EC Number	2.1.1.67
Entrez	4380880
INSDC	ABJ12072.1
NCBI Locus Tag	PA14_27460
UniParc	UPI0000395EFB
UniProtKB Acc	Q02NZ5
UniProtKB ID	TPMT_PSEAB
UniRef100	UniRef100_Q02NZ5
UniRef50	UniRef50_Q9I011
UniRef90	UniRef90_Q9I011

Product

Feature Type	CDS
Coding Frame	1
Product Name	thiopurine S-methyltransferase
Synonyms
Evidence for Translation
Charge (pH 7)	-7.62
Kyte-Doolittle Hydrophobicity Value	-0.135
Molecular Weight (kDa)	24.9
Isoelectric Point (pI)	4.99

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 91 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002735 (520 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_27460 Search term: tpm Search term: thiopurine S-methyltransferase

Human Homologs

Ensembl 110, assembly GRCh38.p14

ENSP00000312304 thiopurine S-methyltransferase [Source:HGNC Symbol;Acc:HGNC:12014] E-value: 2.1e-23 Percent Identity: 31.4

References