Pseudomonas aeruginosa UCBPP-PA14, PA14_30190 (icd)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_30190
Name
icd
Replicon chromosome
Genomic location 2615108 - 2616364 (+ strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq YP_790571.1
GI 116050610
Entrez 4380654
INSDC ABJ11846.1
NCBI Locus Tag PA14_30190
UniParc UPI00000C5771
UniProtKB Acc Q02NB5
UniProtKB ID IDH_PSEAB
UniRef100 UniRef100_Q02NB5
UniRef50 UniRef50_P08200
UniRef90 UniRef90_Q02NB5

Product

Feature Type CDS
Coding Frame 1
Product Name
isocitrate dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7) -9.35
Kyte-Doolittle Hydrophobicity Value -0.116
Molecular Weight (kDa) 45.6
Isoelectric Point (pI) 4.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5M2E OXIDOREDUCTASE 10/12/16 Apo structure of Pseudomonas aeruginosa Isocitrate Dehydrogenase, ICD Pseudomonas aeruginosa 2.7 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 605 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002929 (494 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_30190
Search term: icd

Human Homologs

Ensembl 110, assembly GRCh38.p14
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:5384]
E-value: 1.9e-44
Percent Identity: 33.0

References

No references are associated with this feature.