Pseudomonas aeruginosa UCBPP-PA14, PA14_30230 (clpA)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_30230
Name	clpA
Replicon	chromosome
Genomic location	2617332 - 2619608 (+ strand)
Transposon Mutants	2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	5 transposon mutants in orthologs

Cross-References

RefSeq	YP_790574.1
GI	116050607
Entrez	4380651
INSDC	ABJ11843.1
NCBI Locus Tag	PA14_30230
UniParc	UPI00000C576F
UniProtKB Acc	Q02NB2
UniProtKB ID	Q02NB2_PSEAB
UniRef100	UniRef100_W0YRS1
UniRef50	UniRef50_P0ABI1
UniRef90	UniRef90_Q4K9U8

Product

Feature Type	CDS
Coding Frame	1
Product Name	ATP-dependent Clp protease, ATP-binding subunit ClpA
Synonyms
Evidence for Translation
Charge (pH 7)	-14.48
Kyte-Doolittle Hydrophobicity Value	-0.286
Molecular Weight (kDa)	84.0
Isoelectric Point (pI)	5.89

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database	PseudoCAP
Category
Evidence	ECO:0000015 mutant phenotype evidence
Host Organism	Caenorhabditis elegans
Notes
Infection model	C. elegans slow killing assay.
Reference	22911607

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 604 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002932 (531 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_30230 Search term: clpA Search term: ATP-dependent Clp protease, ATP-binding subunit ClpA

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000294053 caseinolytic mitochondrial matrix peptidase chaperone subunit B [Source:HGNC Symbol;Acc:HGNC:30664] E-value: 1.7e-35 Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14	ENSP00000340385 caseinolytic mitochondrial matrix peptidase chaperone subunit B [Source:HGNC Symbol;Acc:HGNC:30664] E-value: 1.7e-35 Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14	ENSP00000441518 caseinolytic mitochondrial matrix peptidase chaperone subunit B [Source:HGNC Symbol;Acc:HGNC:30664] E-value: 1.7e-35 Percent Identity: 31.2

References