Pseudomonas aeruginosa UCBPP-PA14, PA14_60860 (nfxB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_60860
Name
nfxB
Replicon chromosome
Genomic location 5428030 - 5428593 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_793059.1
GI 116052742
Entrez 4384574
INSDC ABJ13978.1
NCBI Locus Tag PA14_60860
UniParc UPI0000396423
UniProtKB Acc Q02G77
UniProtKB ID Q02G77_PSEAB
UniRef100 UniRef100_Q02G77
UniRef50 UniRef50_P32265
UniRef90 UniRef90_P32265

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator NfxB
Synonyms
Evidence for Translation
Charge (pH 7) -2.66
Kyte-Doolittle Hydrophobicity Value -0.068
Molecular Weight (kDa) 21.0
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
Type A NfxB Type A NfxB mutants are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB). [PMID:8849250] ARO:3004059 protein overexpression model Strict 365.9 98.93 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 24 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004257 (359 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_60860
Search term: nfxB

Human Homologs

References

No references are associated with this feature.