Pseudomonas aeruginosa UCBPP-PA14, PA14_59790 (pvrR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_59790
Name
pvrR
Synonym: RL037
Replicon chromosome
Genomic location 5323630 - 5324829 (- strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14

Cross-References

RefSeq YP_792967.1
GI 116052652
Entrez 4385473
INSDC ABJ13888.1
NCBI Locus Tag PA14_59790
UniParc UPI00000B7D1D
UniProtKB Acc Q02GG9
UniProtKB ID Q02GG9_PSEAB
UniRef100 UniRef100_Q02GG9
UniRef50 UniRef50_Q02GG9
UniRef90 UniRef90_Q02GG9

Product

Feature Type CDS
Coding Frame 1
Product Name
two component response regulator
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -5.89
Kyte-Doolittle Hydrophobicity Value -0.143
Molecular Weight (kDa) 44.8
Isoelectric Point (pI) 6.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration model
Reference 14983043
Source 2
Database PseudoCAP
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse thermal injury model.
Reference 14983043

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 517 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG014998 (97 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_59790
Search term: pvrR

Human Homologs

References

Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.
Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S
Proc Natl Acad Sci U S A 2006 Feb 21;103(8):2839-44
PubMed ID: 16477007
The pathogenicity island encoded PvrSR/RcsCB regulatory network controls biofilm formation and dispersal in Pseudomonas aeruginosa PA14.
Mikkelsen H, Hui K, Barraud N, Filloux A
Mol. Microbiol. 2013 Aug;89(3):450-63
PubMed ID: 23750818
The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes.
He J, Baldini RL, Déziel E, Saucier M, Zhang Q, Liberati NT, Lee D, Urbach J, Goodman HM, Rahme LG
Proc Natl Acad Sci U S A 2004 Feb 24;101(8):2530-5
PubMed ID: 14983043