Pseudomonas aeruginosa PAO1, PA0215
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0215
|
| Name |
Synonym: madL |
| Replicon | chromosome |
| Genomic location | 243431 - 243835 (+ strand) |
| Transposon Mutants | 1 transposon mutants in PAO1 |
| Comment | BIOLOG data shows growth on malonate. Annotation assigns PA0215 and PA0216 as having 71% and 81% homology with MadL and MadM from Malonomonas rubra. |
Cross-References
| RefSeq | NP_248906.1 |
| GI | 15595412 |
| Affymetrix | PA0215_at |
| Entrez | 883110 |
| GenBank | AAG03604.1 |
| INSDC | AAG03604.1 |
| NCBI Locus Tag | PA0215 |
| protein_id(GenBank) | gb|AAG03604.1|AE004459_8|gnl|PseudoCAP|PA0215 |
| TIGR | NTL03PA00216 |
| UniParc | UPI00000C4F9E |
| UniProtKB Acc | Q9I6S3 |
| UniProtKB ID | Q9I6S3_PSEAE |
| UniRef100 | UniRef100_Q9I6S3 |
| UniRef50 | UniRef50_Q87V61 |
| UniRef90 | UniRef90_A6UY10 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
malonate transporter MadL
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 4.95 |
| Kyte-Doolittle Hydrophobicity Value | 1.019 |
| Molecular Weight (kDa) | 13.6 |
| Isoelectric Point (pI) | 10.29 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 30 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000214 (485 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0215
Search term: malonate transporter MadL
|
Human Homologs
References
|
Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.
Berg M, Hilbi H, Dimroth P
Eur. J. Biochem. 1997 Apr;245(1):103-15
PubMed ID: 9128730
|
|
Identification of an Na+-dependent malonate transporter of Malonomonas rubra and its dependence on two separate genes.
Schaffitzel C, Berg M, Dimroth P, Pos KM
J. Bacteriol. 1998 May;180(10):2689-93
PubMed ID: 9573154
|