Pseudomonas aeruginosa PAO1, PA3028 (moeA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3028
Name
moeA2
Replicon chromosome
Genomic location 3392268 - 3393485 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_251718.1
GI 15598224
Affymetrix PA3028_moeA2_at
Entrez 879359
GenBank AAG06416.1
INSDC AAG06416.1
NCBI Locus Tag PA3028
protein_id(GenBank) gb|AAG06416.1|AE004728_2|gnl|PseudoCAP|PA3028
TIGR NTL03PA03028
UniParc UPI00000C58D7
UniProtKB Acc Q9HZH8
UniProtKB ID Q9HZH8_PSEAE
UniRef100 UniRef100_Q9HZH8
UniRef50 UniRef50_G0EZR9
UniRef90 UniRef90_V6ACT7

Product

Feature Type CDS
Coding Frame 1
Product Name
molybdenum cofactor biosynthesis protein A2
Product Name Confidence: Class 2
Synonyms molybdopterin biosynthetic protein MoeA
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.89
Kyte-Doolittle Hydrophobicity Value -0.001
Molecular Weight (kDa) 43.4
Isoelectric Point (pI) 4.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 542 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001762 (887 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3028
Search term: moeA2

Human Homologs

Ensembl 110, assembly GRCh38.p14
gephyrin [Source:HGNC Symbol;Acc:HGNC:15465]
E-value: 1.2e-35
Percent Identity: 30.9
Ensembl 110, assembly GRCh38.p14
gephyrin [Source:HGNC Symbol;Acc:HGNC:15465]
E-value: 1.2e-35
Percent Identity: 30.9
Ensembl 110, assembly GRCh38.p14
gephyrin [Source:HGNC Symbol;Acc:HGNC:15465]
E-value: 1.2e-35
Percent Identity: 30.9

References

Physiological and genetic analyses leading to identification of a biochemical role for the moeA (molybdate metabolism) gene product in Escherichia coli.
Hasona A, Ray RM, Shanmugam KT
J Bacteriol 1998 Mar;180(6):1466-72
PubMed ID: 9515915
Molybdate-dependent transcription of hyc and nar operons of Escherichia coli requires MoeA protein and ModE-molybdate.
Hasona A, Self WT, Ray RM, Shanmugam KT
FEMS Microbiol Lett 1998 Dec 1;169(1):111-6
PubMed ID: 9851041