Pseudomonas aeruginosa PAO1, PA3100 (xcpU)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3100
Name
xcpU
Synonym: pddB
Replicon chromosome
Genomic location 3479721 - 3480239 (- strand)
Transposon Mutants 3 transposon mutants in PAO1

Cross-References

RefSeq NP_251790.1
GI 15598296
Affymetrix PA3100_xcpU_at
Entrez 882756
GenBank AAG06488.1
INSDC AAG06488.1
NCBI Locus Tag PA3100
protein_id(GenBank) gb|AAG06488.1|AE004734_6|gnl|PseudoCAP|PA3100
TIGR NTL03PA03100
UniParc UPI000012BC4A
UniProtKB Acc Q00515
UniProtKB ID GSPH_PSEAE
UniRef100 UniRef100_Q00515
UniRef50 UniRef50_Q00515
UniRef90 UniRef90_Q00515

Product

Feature Type CDS
Coding Frame 1
Product Name
General secretion pathway outer membrane protein H precursor
Product Name Confidence: Class 1
Synonyms PilD-dependent protein PddB
Evidence for Translation
Charge (pH 7) -1.76
Kyte-Doolittle Hydrophobicity Value -0.160
Molecular Weight (kDa) 19.1
Isoelectric Point (pI) 5.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 42 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002494 (353 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3100
Search term: xcpU

Human Homologs

References

Cleavage, methylation, and localization of the Pseudomonas aeruginosa export proteins XcpT, -U, -V, and -W.
Nunn DN, Lory S
J Bacteriol 1993 Jul;175(14):4375-82
PubMed ID: 8331069
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Components of the protein-excretion apparatus of Pseudomonas aeruginosa are processed by the type IV prepilin peptidase.
Nunn DN, Lory S
Proc Natl Acad Sci U S A 1992 Jan 1;89(1):47-51
PubMed ID: 1309616
Protein secretion in Pseudomonas aeruginosa: characterization of seven xcp genes and processing of secretory apparatus components by prepilin peptidase.
Bally M, Filloux A, Akrim M, Ball G, Lazdunski A, Tommassen J
Mol Microbiol 1992 May;6(9):1121-31
PubMed ID: 1588814